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Evaluation of in vitro antimicrobial activities of 2r,6c-diarylpiperidin-4-one (3-hydroxy-2-naphthoyl) hydrazones

Author:

Sylvestre, S and Pandiarajan, K

Subject Area:

Physical Sciences and Engineering

Abstract:

2r,6c-Diarylpiperidin-4-one(3I-hydroxy-2I-aphthoyl)hydrazones 1-8 were screened for their in vitro antimicrobial activity against a panel of pathogenic bacteria (Staphylococcus aureus, Streptococcus pyogenes, Salmonella typhi, Klebsiella pneumoniae and Escherichia coli) and a panel of pathogenic fungai (Candida albicans, Aspergillus flavus, Aspergillus niger and Cryptococcus neoformans) by two fold serial dilution method. DMSO was used as control while drugs Cefotaxime and Miconazole were used as standard drugs for antibacterial and antifungal studies, respectively. Compounds 3, 6 and 7 are more active than the standard drug against all the tested bacterials strains. Compounds 2 and 7 are more active than the standard against all the tested fungal stains.

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