Concerns have been raised globally that human resource management practices do influence employee performance. These concerns have been noted in studies conducted in Ghana, Tanzania Nigeria and other countries of the world. In Kenya the performance in the Kenya Certificate of Secondary Education examinations mean scores in Rachuonyo North Sub County in comparison with neighboring sub counties of Homa Bay County for the past 3 years had been below average (3.11 in 2017, 4.07 in 2018 and 4.36 in 2019) Rachuonyo East (3.4940, 4.672, 4.9468), Rangwe (5.24048, 5.0257, 3.416), Suba (3.5722, 4.4310, 4.3097), Mbita (3.5983, 4.4706, 4.860) and Homa bay sub county (4.2920, 4.860, 4.7904). At the same time, the Teachers Service Commission (TSC) still uses various human resource practices to manage teachers. Concerns have been raised that these practices influence the deteriorating performance hence a study was necessary to establish the extent and degree to which these practices influence teacher instruction performance. The objective of the study was to determine the extent to which Teachers Service Commission disciplinary practices influences teacher performance in public secondary schools in Rachuonyo North Sub County, Kenya. The findings revealed that Teachers Service Commission disciplinary practices had a moderate influence on teachers’ instructional performance. The researchers recommended a thorough refinement of these practices in order to realize full potential of the teachers as they negatively affect teachers’ performance. The study findings are significant to stakeholders in education as they inform policy formulation, review and implementation on Teachers Service Commission transfer, compensation and career progression practices.