Introduction: Life style diseases have been recognized as a clear threat not only to human health, but also to the development and economic growth in many countries. The number of individuals suffering from these diseases has been a steady rise. Chronic diseases of lifestyle are a group of diseases that share risk factors such as unhealthy dietary choices, smoking, lack of physical exercise, sedentary behavior and life-stress. Background of the study: The impact of non communicable diseases on the lives of the people is serious in terms of economic loss of country, loss of life and loss of potentially productive years of life, disability, family hardship and poverty. Objectives: The main objective of the study was to assess the prevalence and influencing factors of lifestyle diseases among middle aged(30-55yrs) among patients in General Ward. Hypothesis: 1,There is no significant relationship between gender and lifestyle diseases.2,Stress in lifestyle diseases.3,Family history and lifestyle diseases. Materials and methods: A cross sectional study was conducted on 87 patients in District Hospital, Thodupuzha. Census method was adopted for selection of sample. Chi-square test and frequency distribution tables were used for the analysis and interpretation. Results and discussion: Males are more victims for the lifestyle diseases than the females in the sample study. Among the sample ,76 patients is having Lifestyle diseases , from the study it is clear that 47.61% of sample population is having the habit of alcoholism and smoking ,majority of patients in the sample population is having hyperlipidemia ,hypertension ,diabetics, joint pains etc . Statistical analysis shows that there is a significant relationship between gender and Lifestyle diseases, stress and lifestyle diseases and family history and lifestyle diseases. Conclusion: The study were conducted to assess the Lifestyle diseases among all patients in a district hospital .Modern life style patterns affects our health in different aspects like physically ,psychologically ,and socially. A healthy lifestyle must be adopted to combat these diseases with proper balanced diet, physical activity, and giving due with respect to a biological clock. Healthy diet, regular sleep, daily activity, and a moderate approach to life’s stressful moments will all lead in the right direction to a healthy lifestyle.