This research aims to study under the context of digital technology & COVID-19 pandemic disruption1) the demanding of SDG’scross cutting issues in Thailand that ODL can facilitate; 2) how STOU use ODL to serve the SDG’ s cross cutting issues; and 3) to recommend how to scale up ODL to serve the SDG’scross cutting issues. Qualitative research via STOU-ODL case study approach was used to analyze how ODL of STOU serve the demanding SDG’s cross cutting issues. Results found 1) the demanding of SDG’s cross cutting issues in Thailand respectively are 1) Goal 4: Quality education; Goal 3: Good health and well-being ; Goal 5: Gender equality; Goal 1: No poverty; Goal 2: Zero hunger; Goal 9: Industry, innovation and infrastructure; Goal 10: Reduced inequality ;Goal 11: Sustainable cities and communities; Goal 16: Peace, justice and strong institutions; and Goal 17: Partnership; 2)STOU use ODL to serve the SDG’s cross cutting issues by embedded with ICT to offer all types of educational programs : (1) Formal, (2) Non-formal &Informal educations to cover all groups of people in Thailand including all the marginalized can be easily accessed to all kinds of SDG’s cross cutting issues for their new required knowledges and skills, more opportunities, and better quality of life. 3) ODL must be appropriate designed with partnership model to fit well with all contexts of the SDG’s cross cutting issue i.e. in-time & demanded base issue, friendly & appropriate pedagogy, agile administrative & management, and all kinds of participatory contribution. Some examples of STOU-ODL’s academies to serve all the SDG’s cross cutting issues are Smart MOOC, Smart Ageing, Smart Farmer, Smart Youths & Young Women Entrepreneur, and others.