In the present work, the hypolipidemic activity of the Apium graveolens and Cymbopogan flexuosus was evaluated. It showed significant decrease in the levels of serum Total cholesterol (TC), Triglycerides (TG), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) and significant increase in the level of High density lipoprotein (HDL) when administered orally for 28 days to streptozotocin induced hyperlipidemic rats at a dose of 200, 400, 600 mg/kg. As Apium graveolens and Cymbopogan flexuosus have hypolipidemic activity, these plants can be used as potential medicine for cardiovascular diseases.