CALL FOR PAPERS

Author Information

CERTIFICATE

IMPACT FACTOR 2019

Subject Area

Life Sciences / Biology
Architecture / Building Management
Asian Studies
Business & Management
Chemistry
Computer Science
Economics & Finance
Engineering / Acoustics
Environmental Science
Agricultural Sciences
Pharmaceutical Sciences
General Sciences
Materials Science
Mathematics
Medicine
Nanotechnology & Nanoscience
Nonlinear Science
Chaos & Dynamical Systems
Physics
Social Sciences & Humanities

Why Us? >>

Open Access
Peer Reviewed
Rapid Publication
Life time hosting
Free promotion service
Free indexing service
More citations
Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Huhs1015 reduces pkm2 protein due to autophagic degradation in gastric cancer cells

Author:

Tomoyuki Nishizaki

Subject Area:

Life Sciences

Abstract:

The newly synthesized anticancer drug HUHS1015 decreased pyruvate kinase M2 (PKM2) protein in MKN28 and MKN45 human gastric cancer cells in a treatment time (10-60 min)-dependent manner. The effect of HUHS1015 was clearly inhibited by the autophagy inhibitor 3-methyladenine. HUHS1015 increased LC3-II, that is required for the autophagosome formation in the autophagic processes, in a treatment time (10-60 min)-dependent manner. PKM2 deficiency induces cell death including apoptosis and activated caspase-3, -4, -8, and -9. Taken together, the results of the present study show that HUHS1015 decreases PKM2 protein due to autophagic degradation, which contributes to caspase activation and apoptosis induction in MKN28 and MKN45 cells.

PDF file: