Background: The 2019 coronavirus disease (COVID-19) epidemic has raised international concern. Apart from the evident physical symptoms in infected cases, it has caused serious damage to public mental health. Mental health is becoming an issue that cannot be ignored in our fight against it. Present study aimed to explore the prevalence and factors associated with mental health condition and social support among hospitalized COVID-19 patients. Methods: A total of 158 patients diagnosed with COVID-19 were included in this study. Current study assessed the depression, anxiety and stress symptoms using the DASS 21 and social support using the Perceived Social Support Scale among patients at admission. The multivariate linear regression analyses were performed to identify factors associated with symptoms of anxiety and depression. Results: Of 158 participants, majority of the patients had the symptoms of depression, anxiety and stress symptoms. Bivariate correlations analysis highlighted that significant low social support was correlated with anxiety (r=-0.166,p<0.05) and stress (-0.238,p<0.01) symptoms among COVID-19 patients. The multiple linear regression analysis highlighted that social support (β =-1.524,p=0.044) is associated with Depression. Further oxygen saturation (β =0.374, p=0.043), and social support (β =-1.714,p=0.044) were associated with anxiety and oxygen saturation (β =0.363, p=0.043), age (β=0.072,p=0.043), and social support (β =-2.259,p = 0.004) were the factors associated with stress. Conclusion: The finding suggested that mental health symptoms are prevalent among hospitalized COVID 19 patients. Mental health concern and appropriate intervention is also required for patients along with the treatment regimen of COVID 19 during the epidemics.