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Role of antioxidants in detoxication of hexavalent chromium toxicity in laboratory rats

Author:

Dr. Dharmendra Kumar

Subject Area:

Life Sciences

Abstract:

Antioxidative protection offered by three nutrients viz: α-tocopherol (vitamin E), reduced glutathione (GSH) and selenium (Se) against hexavalent chromium {Cr(VI)} toxicity has been studied in laboratory rats. Chromium like other transition metal ions induced oxidative stress in liver and kidney. However, treatments with antioxidants inhibited lipid peroxidation and activated serum transminases and glutathione -S-transferases activity in both the organs. Selective preferences were shown by these antioxidants for these parameters in each organs. Our results confirm that antioxidants offer protection by different mechanisms. Disturbances in cellular equilibrium of anti and pro-oxidants caused by chromium can be overcome by antioxidants with certain preferences.

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