Tetracycline as a root Biomodifying agent

Periodontal regeneration is the ultimate goal of periodontal therapy. For this purpose, numerous modalities have been advocated including, the modification of the root surface that is biomodification procedures in order to detoxify, decontaminate, and demineralise the root surface. Tetracycline has been well known as a broad spectrum antibiotic, although its effect as a root conditioning agent is yet to be explored. Hence, to explore the same, EBSCO HOST was searched for entries since 1966 – 2014, which included:- Journal of Periodontology, Annals of Periodontology, Periodontology 2000, Journal of Clinical Periodontology, International Journal of Periodontics and Restorative dentistry, Journal of Indian Society of Periodontology and Journal of Periodontal Research. A total of 11 studies were reviewed, out of these 11 studies, only, 4 reported evidence of regeneration for tetracycline. It was found that the role of tetracycline as a root biomodifying agent in regeneration is still controversial and questionable.