The issue of person organization fit has been considered as one of the paramount research areas in organizational behavior. Various research undertaken in the area have indicated that the extent to which the abilities and values of individuals fits with the demands of the job environment greatly affects employees commitment and their intention to continue working in a given setting. The current study was initiated in view of assessing the interplay between P-O fit and turnover intension of academic professionals in academic institution, by taking evidence from Hawassa University. The study was cross sectional in nature and made use of survey instruments developed by prominent researchers in the area. The result of the study indicated that, although no to a large extent, there exists misfit between the desire and values of academic professionals and the demand and values of the academic institution. Further the results of the study indicated that P-O fit is an important predictor of academic professional’s turnover intension . The outcome of the research is expected to be a valuable input in the process of designing and implementing employee oriented human resource strategies by academic professionals in the country.