CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Combination pharmacokinetics and pharmacodynamics of dihydroartemisinin-piperaquine and primaquine in patients with uncomplicated falciparum malaria in halmahera Indonesia

Author: 
Arend Laurence Mapanawang, Mustofa, Mahardika A Wijayanti, Rina Handayani, Lukman Hakim, Maikel Killing, Aleksander Maengkom, Frangky Mapanawang, Fernandes Sambode, Henderina Maengkom and Sarah Mapanawang
Subject Area: 
Health Sciences
Abstract: 

Malaria remains one of the deadly diseases in Indonesia. In its attempts to cure malaria, the government has implemented the DHP formulation (dihydroartemisinin-piperaquine) added with primaquine. However, no study has been carried out on the pharmacokinetics and pharmacodynamics of this combination. The purpose of this research is to compare absorption rate constant (Ka), time of maximum concentration observed (Tmax), elimination half-life (t1/2), volume of distribution (VD), clearance (CL), plasma maximum concentration (Cmax), and area under curve (AUC) of the DHA-piperaquine (DHP) and primaquine combination in 12 uncomplicated falciparum malaria patients and the pharmacological effects. Random clinical tests were conducted with an experimental method to 12 patients from September to December 2014. Blood samples were taken sequentially, starting from day 0 to day 28, and then tested using LC-MS to measure the kinetic concentration. The results showed that the kinetic profile of DHA, piperaquine, and primaquine synergized well with no contradictions recorded as the patients were cured without any side effects. The DHP-primaquine combination (Cmax and Auc) was able to clean the parasite in just two days of treatment and showed that there was a significant relation (P = 0.001 < 0.05 AND 0.010 < 0.05) between the drug content and parasite clearance. The pharmacological effect was APCR, with 100% of treatment success.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran