Endodontics encompasses the study and practice of the basic and clinical sciences of the biology of the normal dental pulp and the etiology, diagnosis, prevention treatment of diseases and injuries of the dental pulp along with associated periradicular conditions. Endodontics has evolved tremendously in the past decade and its applications have immensely improved the quality of dental treatment. Hence exploring the different aspects of the principles of endodontics, tackling certain challenges will help to boost its development with the advantage of innovations in research and technology. This paper reviews the various advancements that can change the course of endodontics, as well as the challenges which when tackled can solemnize its future