Objective: To compare the efficacy of HiOra-GA gel with that of Hexigel for the management of patients with gingivitis. Methods: 60 patients of either sex aged more than 18 years and who are enrolled with diagnosis of gingivitis will be included in the study under 2 groups of 30 patients each and consecutive sampling will be done for the recruitment of patients. Group I patients will be given HiOra-GA gel and Group II patients will be given Hexigel which are to be taken over the index finger and applied over the gums twice daily for a period of four weeks. Thus, the efficacy of HiOra-GA gel in gingivitis will be compared with that of Hexigel. Results: On comparison of the mean differences between both the groups using unaired t test a mean value of 1.187±0.02 for group 1 and a mean value of 1.188±0.01 for group 2 was found, with t value of 0.260 and is insignificant (p>0.05). Conclusion: It can be concluded that HiOra-GA gel and Hexigel are equally effective in the treatment of gingivitis. Further studies should be carried out with larger sample sizes and longer follow-ups to compare the efficacies of both the drugs.