
The aim of the study was to investigate genetic polymorphism in leptin receptor gene, (LEPR) and the risk of bladder cancer through a retrospective case-control analysis that consisted of 270 cases of bladder cancer and 252 controls. For the LEPR Gln223Arg polymorphism, no significant differences were observed in the genotype frequencies with regard to bladder cancer. The interaction of LEPR Gln223Arg polymorphism also did not show any significant associations either with environmental factors or with histopathology. This is the first case-control analysis carried out on Single Nucleotide Polymorphism in leptin receptor gene and carcinoma of urinary bladder so far. No other studies pertaining to same are available in the literature.