Indonesia is famous as an area highly rich in natural resources, both in terms of quantity and diversity. The government is striving to improve and promote the use of Indonesia’s indigenous sources of nutrients and the use of natural herbal medicines Indonesia. The use of herbal medicine is closely related to traditional medicine that is inherited across generations as well as the manufacture and sales made by shamans. Historically, the use of herbal medicine began in 5000 BC by the Sumerians who have been able to identify some of the plants. This study aims to identify estrone hormone in Gedi (Abelmoschus manihot, Jatropha multifida, euphorbiaceae) leaves, typical vegetable produces known to be useful to expedite the delivery process of pregnant women. Gedi leaves (Abelmoschus manihot Jatropha multifida, Euphorbiaceae) is a kind of leaves that become food such as vegetables by the people of Micronesia, including Indonesia, especially the eastern part of Indonesia such as Manado in North Sulawesi, Halmahera in North Maluku, and Papua. Papuans even make the leaves as the main vegetable to complement food. This research can make a valuable contribution to the development of the medical world associated with obstetrics and gynecology. The leaves containestra-1,3,5(10)-trien-17-one,a compound that affects estrogen hormone in pregnant women, especially during the third trimester to expedite the delivery process, amounted to 3.48%. Empirically, people in eastern Indonesia have been using the leaves as a traditional medicine to expedite the delivery process for generations. The identification is done by a combination chromatography, i.e., Gas Chromatography Mass Spectrophotometry (GC-MS).