CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Mapping of anti-inflammatory phytochemicals on cancer drug target network using systems biology approach

Author: 
Amit R. Rupani, Biplab Bhattacharjee, Priyanka Priyadarshini
Subject Area: 
Life Sciences
Abstract: 

In the field of cancer biology, the drug and their targets holds a role of paramount importance. Biological network helps in the evaluation and validation of cancer drugs and their targets. It is usually created to simplify the studies. In the present study we have created a protein-ligand interaction network where ligands and proteins are anti-inflammatory phytochemicals and cancer inducing drug targets respectively. The objective of the study was to identify the highest interacting cancer druggable target protein in the protein-ligand network and an appropriate anti-inflammatory phytochemicals against it. In order to procure the cancer inducing drug targets, we found anti-inflammatory drugs using literature survey. In total, 49 anti-inflammatory drugs were identified as the most critical. Drugbank was used to obtain the targets of all the anti inflammatory drugs collected. 35 protein targets were identified. Cancer inducing property of these targets was evaluated using Human Cancer Protein Interaction Network (HCPIN) database. 16 proteins were found to be cancer inducing proteins. We obtained structures of 11 proteins from Protein Data Bank (PDB) in the form that can be easily docked using ligands in Quantum3.3.0. These 11 proteins served as cancer inducing target proteins for our study. The anti-inflammatory phytochemicals were collected from a wide range of publishers and databases. The survey resulted in 157 anti-inflammatory phytochemicals. All these phytochemicals were subjected to multi receptor docking using Quantum3.3.0 docking software where cancer inducing drug targets served as receptors. The most suitable drug-like compounds were mapped along with the drug targets using VisANT. The protein found to take part in most inter-network interactions was Beta- Catennin 1. The phytochemicals that had the best interactions with Beta- Catennnin 1 were Chicoric acid and Digoxin. Still further investigation with respect to pharmacological and phytochemical profile of these plant derived compounds needs to be carried out to concrete evidence of their drug like behavior against Beta- Catennnin 1 induced cancer.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran