Synthesis and study of anti-tubercular activity of some newly synthesised4-thiazolidinone and 2-azetidinone derivatives

A series of 2-azetidinone and 4- thiazolidinone derivatives having piperazine moiety have been prepared to evaluate the anti-tuberculosis activity. Various Schiff bases have been prepared from N-ethylpiperazine on condensation with p-chloroaniline in absolute alcohol in presence of K2CO3 and subsequent reaction with various aldehydes (4a-4j).These Schiff bases on cyclocondensation with thioglycolic acid in 1,4-dioaxne gave 4-thiozolidinones (5a-5j). Similarly, Schiff Bases (4a-4j) on cyclocondensation with chloroacetic acid in presence of triethyl amine gave the 2-azetidinones (6a-6j).