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Acute And Sub Acute Toxicity Studies Of Gandhaga Chunnam On Swiss Albino Rats

Author: 
Om Sakthi, T., Mohamed Musthafa, M. and Mohamed Hussain, M.
Subject Area: 
Health Sciences
Abstract: 

Psoriasis is a chronic, non- infectious skin disease affects both sexes. Gandhaga Chunnam (GC) has been employed as a traditional remedy for psoriasis which is a siddha herbo-mineral formulation contains gandhagam (sulphur) in its calcinated form. GC is further evaluated for toxicological effects. Acute and sub acute toxicity studies with GC were carried out on Swiss albinorats. During acute toxicity study there were no any adverse effects found in the general behavior and no mortality at any dose level given(2000 mg/kg/b.wt). In sub acute toxicity study in the dose of(200,400 mg/kg/b.wt) didn’t cause any changes in haematological & bio –chemical parameters like leucocyte count, free fatty acid, plasma and urine, creatinine level. Further histo-pathological examination of vital organs should normal suggesting no morphological disturbances. It can be considered that GC is safe and non-toxic.

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