CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Acute toxicity study and parasympatholytic effect of burantashi ethanol extract on an isolated smooth muscle preparation

Author: 
Nwankudu, O. N., Nwankwo, A. A. and Ijioma, S. N.
Subject Area: 
Health Sciences
Abstract: 

The acute toxicity and parasympatholytic effects of a powder made from the stem bark of Pausinystalia yohimbe, popularly called Burantashi was evaluated using carefully designed in vivo charcoal meal transit in rats and in vitro isolated tissue models. Results obtained revealed an acute toxicity value of about 1000mg/kg body weight. All doses of Burantashi ethanol extract (BEE) also elicited a significant (p< 0.05) relaxation effect on the smooth muscles of the rabbit jejunum. In the in vivo work, 100, 200 and 400mg/kg of BEE inhibited the movement of charcoal meal in the rat’s gastrointestinal tract by 8.61±0.89, 12.30±1.06 and 25.06±1.30% respectively and compared favorably with the effect of atropine (1mg/kg) which yielded a mean % inhibition of 34.27±4.15%. On isolated rabbit jejunum, BEE significantly inhibited rhythmic contractions at all final bath concentrations (FBC) administered. BEE also significantly blocked the contractile effect of acetylcholine but did not significantly affect that of propranolol (a non selective beta receptor blocker). The results obtained suggest that excessive and habitual consumption of burantashi could be deleterious to health, but mild to moderate use/consumption could be of medicinal value. The extract may contain substances with potent parasympatholytic properties which may be of value in the management of diseases associated with excess activity of the parasympathetic arm of the autonomic nervous system, and may yet serve as template for the development of more synthetic parasympatholytics of clinical significance.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran