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Alzheimer disease & genetics: A mini review

Author: 
Wasfy Jameel Hamad, Hani JameelHamad and Mohammed Omar Ibrahim
Subject Area: 
Life Sciences
Abstract: 

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases AD is characterized by adult-onset progressive dementia, beginning with subtle memory failure that becomes more severe and is eventually incapacitating. The most common neuropathological feature of AD is the presence of neurofibrillary tangles and amyloid deposits that form plaques and cerebrovascular accumulations. AD is divided into familial and sporadic forms. AD is considered familial when more than one person in a family is affected, while sporadic refers to AD cases when no other cases have been seen in close family members. It has been over 100 years since the first cases of AD were described, and since then much has been discovered about the molecular nature of the disease. The genetic control of complex diseases is becoming more apparent as previously unidentified mutations in the human genome are described. As the genetic control of AD is uncovered, improved therapies may also be uncovered

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