
Anesthetists should have to face with different challenging sickle cell anaemia cases due to the nature of the disease. Thorough understanding of the pathophysiology of sickle cell crisis and organs dysfunction accompanied sickle cell anaemia will result in a decrease in perioperative morbidity and mortality. Also, proper preoperative assessment and evaluation with a multi-disciplinary team approach will carry out good optimization enabling early detection and management of perioperative complications.