Background of the study: The increasing amount of medical error has become a disturbing atmosphere, whether or not it is evident or harmful to the patient. The reason behind is due to an association with inexperienced physicians and nurses, this is why Knowledge acquisition and skills maintenance are important in bringing down the error. Traditionally this is taught by using low fidelity mannequins, but due to a technological advancement it has move towards high fidelity mannequins, which allows for repetitive practices, utilizing different scenarios with various levels of difficulty. Aim: To find out the opinions on low versus high fidelity simulation among the nursing students. Material and method: A non-experimental (Comparative research design) was conducted at selected nursing colleges, 50 nursing student were exposed on both low and high fidelity simulators in the skills laboratory after which a self-report technique was implied using 5 point Likert scale for obtaining the opinions from nursing students. The reliability of the tool was done using cronbach’s alpha and found to be 0.784. Result: The study revealed that the Low fidelity opinion mean score (11.82 ± 1.18) which is 58.04% and high fidelity opinion mean score (17.71 ± 1.424) which is 88.58%. The unpaired’t’ test showed differences in opinion on Low fidelity simulation and high fidelity simulation among nursing students (t value = 29.358). Chi square test also revealed that there was no significant association between opinion score and socio demographic variables like age and gender. However a significant association was found between the opinion score and demographic variables like previous training and workshop, which were (ᵧ2= 7.64 and 4.80) respectively. Conclusion: The study concluded that, High fidelity simulation is more effective than the low fidelity simulation according to the opinions of the nursing students.