CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Anti-inflammatory activity of novel hdac8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles with glycine/alanine hybrids

Author: 
Vijaya Rao Pidugu, Nagendra Yarla, Swathi Putta, Arunasree M Kalle and Krishna Satya, A.
Subject Area: 
Life Sciences
Abstract: 

Histone deacetylases (HDACs) are the regulators of inflammation and HDAC inhibitors are shown to be anti-inflammatory agents. Previously, we designed and synthesized a series of novel glycine and alanine hybrids of 2,5-disubstituted 1, 3, 4-oxadiazoles as class I HDAC inhibitors. All the compounds synthesized (10a-j) showed moderate HDAC8 selectivity and anti-tumor activity. Here we evaluated the anti-inflammatory potency of the compounds on E. coli-infected mouse macrophage, RAW 264.7, cells. Among the 10 compounds (10a-j), compounds 10f and 10h alone did not inhibit the macrophage proliferation. Further studies using 10f and 10h showed reduced colony-forming units (CFU) of bacteria isolated from the infected macrophage and inhibition of the COX-2 inflammatory protein levels along with inhibition of the pro-inflammatory cytokines (IL-12, TNF-, IFN-γ). Further in vivo studies using carrageenan-induced paw edema in rat model demonstrated a significant reduction in the paw edema at 20 mg/kg body weight when compared to untreated control. The study results thus signify that compounds 10f and 10h with moderate HDAC8 inhibitory activity also possess potent anti-inflammatory activity.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran