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Antidiabetic potential of diets containing Vernonia amygdalina leaves in Streptozotocin- induced diabetic Wistar rats

Author: 
Akpan, H. D. and Dan, P. H
Subject Area: 
Life Sciences
Abstract: 

This study determines antidiabetic potential of diets containing Vernonia amygdalina leaves in Streptozotocin- induced diabetic rat model. Fifty albino wistar rats were divided into five groups with 10 rats in each group. Group 1 and Group 2 (normal and diabetic control respectively) were fed with control diet; Group 3 and 4 (diabetic) were fed with diets containing Vernonia amygdalina leaves at 5% and 7.5%, respectively. Group 5 (diabetic) was fed with control diet and administered insulin. Feed and water were given ad- libitum for 28 days. Fasting blood glucose, plasma glucose, insulin, c-peptide, hemoglobin and glycosylated hemoglobin were determined using standard methods. Results showed that diabetic rats consuming Vernonia amygdalina leaves had significant (P<0.5) increase in plasma insulin, c-peptide and hemoglobin concentrations relative to the diabetic control. Diabetic rats consuming Vernonia amygdalina had significant (P < 0.5) reduction in the level of plasma glucose and glycosylated hemoglobin concentrations relative to the diabetic control. The results for Vernonia amygdalina diets were similar to insulin on the measured parameters except for plasma glucose concentration and their levels were not significantly different (P >0.5) when compared to the normal control. It was concluded that diets containing Vernonia amygdalina leaves are potential antidiabetic agents.

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