Background: Road traffic accidents are common cause of head injuries followed by fall and combat injuries nearly 20 percent of traumatic brain injury patients develop seizures ,which may be early onset or late onset. Materials & Methods: Retrospective comparison of role of antiepileptics to control seizures in traumatic brain injury in a tertiary care centre the effectiveness to control seizures in traumatic brain injury patients admitted in rajiv Gandhi government general hospital either prophylactically or treatment is analysed. Results and Principle Conclusion: Phenytoin is drug of choice for early onset seizures in traumatic brain injury patients levetiracetam is a viable alternative, carbamazepine and sodium valproate are used as second line drugs.