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An assessment study on extraction of glucosamine from potential source and effect of glucosamine activity on administration of conventional drugs

Author: 
Rashmi Kurli, Shruti Humsagar, Roopa Melinamani, Uday M. Muddapur, Hrishikesh Mungi and Shanmuga Priya¬¬, V. G.
Subject Area: 
Life Sciences
Abstract: 

Glucosamine has attracted much attention owing to its therapeutic activity in osteoarthritis and widely used dietary supplement. A search for a new potential source is going on due to the allergies caused by glucosamine extracted from shell fish and to reduce the cost involved in extraction of vegetarian glucosamine which are presently used as sources. The present investigation describes the effective extraction of glucosamine from sweet potato. (Method) A maximum yield of 16.3g/kg was obtained. The study also focuses on effect of conventional drugs in interaction between cytochrome P450 receptors- Cyp2C9 and Cyp3A4 with glucosamine. In the presence of conventional drugs, the E-value of binding between glucosamine and Cyp2C9 receptor was increased by 20% and with Cyp3A4 receptor it was increased by 34% which indicates the decrease in affinity between them. Hence, the current research reports two vital findings with respect to extraction and efficacy of glucosamine in presences of conventional drugs.

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