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Association of PIM-2 and NF-κB overexpression with poor clinical outcome in Egyptian patients with acute myeloid leukemia

Author: 
Hadeer A Abbassy, Hanaa M Donia and Omar M Ghallab
Subject Area: 
Health Sciences
Abstract: 

Acute myeloid leukemia (AML) is a highly fatal disease. Therefore, accurate predictors of clinical outcome can contribute to the design of appropriate treatment for individual patients. Proviral integration of Moloney virus-2 (PIM2) is a key mediator of hematopoietic cell growth and apoptotic resistance. Nuclear factor kappa B (NF-κB) activation by Pim-2 is required for its antiapoptotic function. The aim of the present study was to assess PIM-2 and NF-κB ex¬pression in adult patients with AML and to determine their correlation with the induction outcome. This study was conducted on 90 patients with de novo AML. Using real time polymerase chain reaction RT-PCR, PIM2 and NF-κB expression was analyzed. Patients were followed up by bone marrow examination on day 28 after induction to assess the response to chemotherapy. There was an overexpression of both PIM-2 and NF-κB in patients before induction. After induction, those who failed to respond to induction therapy had higher expression levels than those who achieved complete remission. A significant positive correlation was evident between their expression in patients with AML and with induction failure. In conclusion overexpression of PIM-2 and NF-κB in patients with AML is associated with resistance to induction therapy and low complete remission rate.

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