Neoplastic lesions of the oral cavity mostly need surgical treatment which requires resection of the tongue, floor of the mouth, part of maxilla and mandible. Mandibulectomy & radical neck surgery involves the comprehensive loss of tissues and affiliated functions. So the rehabilitation of such patients is more challenging as there are many limitations like limited tissue coverage and retention, deviation towards resected site, loss of control on mandibular movements that alters the normal function. Dentulous patients can be retrained to achieve acceptable maxillomandibular relationship with the help of guide flange or ramp prosthesis. This paper describes the basic approach for the prosthodontic rehabilitation of a dentulous patient with hemimandibulectomy to achieve better function.