Omega-3 fatty acids are potent antioxidants and exhibit a biological activities including neuroprotective, anti-oxidant, anti-apoptotic and anti-inflammatory properties, and have been suggested to be useful in treatment of several diseases. The present study has been undertaken to investigate the protective effect of omega-3 fatty acid (750mg/kg bwt.) against lead acetate (7.5mg/kg bwt.) induced impairment in neurotransmitters and neurobehavioral in wistar rats. The levels of dopamine (DA), nor-epinephrine (NE) and serotonin (5-HT) were evaluated in brain regions (cerebral cortex and cerebellum) of adult male wistar rats. The result showed that the administration of acute dose of lead acetate (7.5 mg/kg bwt.) induced a significant (P<0.05) decrease levels of DA, NE, and 5-HT in the brain region. Treatment of rats with omega-3 fatty acid produced an improvement in most of the studied parameters as well as the neurobehavioral features. In conclusion our data showed that dietary omega-3 fatty acid provide protection on lead-induced behavioral and neurological effects.
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