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Cancer antigen 15.3 levels in alcoholic liver cirrhosis

Author: 
Kavitha, S., Anitha, M. and Vishwanath, H. L.
Subject Area: 
Life Sciences
Abstract: 

CA 15.3 is a tumour marker useful in monitoring therapy and disease progression in metastatic breast cancer patients. Literature has shown that CA 15.3 levels are affected by liver diseases. This study was a case control study conducted to evaluate CA 15.3 levels in 30 cases of liver cirrhosis in Victoria Hospital attached to Bangalore Medical College and Research institute. There was a statistically significant increase in CA 15.3 levels in cirrhotic patients when compared to age and sex matched healthy controls. Neither cytolysis nor cholestasis, as measured by transaminases and bilirubin respectively, appeared to be related to the increase of the antigen in our patients. A poor metabolism of CA 15.3 due to liver insufficiency can play a role in the increase of this antigen in liver cirrhosis patients. We conclude that liver cirrhosis does not substantially limit the usefulness of this marker in patients with breast cancer as increase in CA 15.3 levels above the reference range was seen in only a small proportion of the patients.

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