“Candida Overgrowth Syndrome” is an upcoming and more of common condition found particularly in youngsters who are on long term broad spectrum antibiotics for the treatment of acne and chronic sinusitis. Candidas are budding yeast cells which normally inhabit our gastrointestinal tract along with the other normal microbial flora. Overgrowth of Candida is made possible by overuse or misuse of antibiotics, a dysfunctional immune system or gastrointestinal distress. The striking feature is that the patients develop too many generalized, gastrointestinal and behavioral symptoms, with all their blood and other diagnostic tests negative. Timely and evidence based diagnosis of “Candida Overgrowth Syndrome” helps in accurate and timely treatment of the patient, thus avoiding unnecessary tests and medications. Here we present such a case of a young boy who landed up with “Candida Overgrowth Syndrome” after long-term intake of antibiotics taken for treating acne.