A case of synchronous primary uterine endometrial carcinoma and bilateral ovarian clear cell carcinoma

Introduction: The endometrial carcinoma can present as abnormal excessive uterine bleeding. However its occurrence with clear cell carcinoma of ovary is rare. Equally rare is the occurrence of bilateral clear cell carcinoma and the coexistence of ovarian endometrioid carcinoma. Materials and Methods: A 40 year multiparous woman with abnormal excessive uterine bleeding and suspected to have leiomyoma underwent hysterectomy. On operation table, she was found to have a malignant looking left ovarian mass and so hysterectomy with bilateral salpingo-oophorectomy was done. Grossly, the uterus was having irregular endometrial lining and a superficial soft granular creamish mass filling the entire endometrial cavity. The left ovary had predominantly soft solid creamish area. Right ovary had predominantly cystic areas and one solid firm nodule. Sections were given and processed further as per our laboratory protocol and stained with H & E. Results: On microscopic examination, uterus showed morphology of well differentiated endometrial carcinoma limited to endometrium. Left ovary showed morphology of clear cell carcinoma with small area of endometrioid carcinoma. Right ovary showed predominantly normal morphology, nodule like area showed morphology of clear cell carcinoma. Both uterine and ovarian neoplasm were primary. Conclusion: This case is presented here owing to its rarity. Differentiation between the primary and secondary neoplasm in the synchronous neoplasms is important because it would influence on cancer staging, management, and prognosis.