Krimi Granthi is explained as one of the nine Sandhigata netra roga. It is a common clinical condition comes across in general ophthalmic practice, which can be correlated to Blepharitis. Its cardinal features are Kandu, Daha, Pakshmapota and Pooyasrava Granthi with Krimi. Study carried out to evaluate the efficacy of Pratisarana with Triphaladi Rasakriya & Ela Choorna after Darvi Seka in the Management of Krimi Granthi. 20 patients in each group fulfilling the inclusion criteria of Krimi Granthi were selected from O.P.D and I.P.D of Shalakya Tantra, SKAMCH & RC, Bangalore. Darvi Seka done for 5 days in both the groups followed with Triphaladi Rasakriya Pratisarana and Ela Choorna Pratisarana in each group respectively for 7 days.Overall the effect of treatment was statistically highly significant After Darvi Seka, After Pratisarana and at Follow up on all the parameters. Though both groups showed highly significant differences, within the group analysis however on comparing the t- values it can be inferred that Group A has showed better results when compared to Group B on Burning sensation, Congestion and Scaling. Whereas on Itching, Lacrimation, photophobia and lid margin edema Group B has showed better result than Group A. But at the time of follow up Group A has showed better result than group B. Triphaladi Rasakriya Pratisaarana was Marginally better than Ela choorna Pratisarana, due to the combination of Chakshusya, Kandugna, Vranaropana drugs which proved beneficial for sustained duration and no any adverse effects noted in the both groups.