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Comparison of serum magnesium and HbA1c levels in patients with type-2 diabetes mellitus

Author: 
Dr. Gayatri, A., Dr. Senthil Kumari, K. R. and Dr. Rasheeda, A.
Subject Area: 
Health Sciences
Abstract: 

Introduction: Diabetes mellitus comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. The metabolic dysregulation associated with DM causes secondary pathophysiologic changes in multiple organ systems that impose a tremendous burden on the individual. Amongst the electrolytes, magnesium merits special attention. Micronutrients have been investigated as potential, preventive and therapeutic agents for type 2 diabetes mellitus and their complications. The aim of the study is to evaluate serum magnesium and HbA1c levels in type-2 diabetes. Materials and Methods: This case control study was carried out in the Department of Diabetology, Kilpauk Medical College, for a period of 1 year for 60 type 2 diabetic patients without complications. For comparison, 30 age and sex matched apparently healthy non diabetic subjects were also studied. Serum magnesium estimation was done by Colorimetric method with Chlorophosphonazo III and HbA1c was done by high performance liquid chromatography in a standard laboratory. Results: Serum magnesium levels were lower in patients with diabetics when compared with controls with significant p value. On comparing HbA1c levels with serum magnesium it is inferred that as the HbA1c level increases, serum magnesium decreases. Conclusion: Magnesium depletion has a negative impact on glucose homeostasis and insulin sensitivity in diabetic patients as well as may increase risk of secondary complications. So it is prudent to monitor magnesium routinely in this patient population and treat the condition whenever possible, it is frequently over looked and undertreated.

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