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Confirmation of preclinical studies data on tioureidoiminomethylpyridinium perchlorate (perchlozon) in clinic

Author: 
Maria Pavlova, Tatiana Vinogradova, Anna Starshinova, Nadezhda Sapozhnikova, Irina Chernokhaeva and Ludmila Archakovaand Piotr Yablonskii
Subject Area: 
Health Sciences
Abstract: 

In accordance to international classification Tioureidoiminomethylpyridinium perchlorate (Perchlozon) belongs to thioacetazone group. In vitro Phz demonstrated significant inhibiting effect on viability of drug-resistant mycobacteria strains of TB. In the reported clinical study, which was performed in 2013-2014, 49 patients with MDR lung tuberculosis were enrolled. The patients were divided in two groups: Group I (main) 25 patients were administered Phz in addition to 6 other anti-tuberculosis drugs; in Group II (comparison) 24 patients received 6 anti-tuberculosis drugs. Efficacy of treatment (which was assessed by cessation of bacterial excretion in sputum) was higher in Group I vs. Group II after 3 months (72.4 % (21) vs. 52% (13)) and by 6 months (86.2% (25) vs. 68% (17). Efficacy of treatment with Phz was 72.4% in complex with other anti-tuberculosis drugs.

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