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Cystatin c in preeclampsia: A case control study

Author: 
Dr. Dhokikar Gajanan Digambarrao, Dr. Ingale Pramod W and Dr. Birla Varsha H
Subject Area: 
Life Sciences
Abstract: 

Background: Preeclampsia is one of the common complications in pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. It is a multisystem disorder with renal failure as one of its major complication. Assessment of renal function is important in the evaluation of these patients. Cystatin C, a chain of 120 amino acids is a new marker of renal function. Present study conducted to evaluate diagnostic value of Cystatin C serum levels as alternative marker of renal function in Pre-eclamsia (PE) and compare it with the traditional markers of renal function, Creatinine and BUN. Present study might give us an early marker of renal dysfunction in preeclampsia. Material and Methods: In this case-control study markers of kidney function were investigated in two groups: one with newly diagnosed cases of preeclampsia PE (n = 50) and the other of healthy primigravida as controls (n = 50) of same gestational age. Serum Cystatin C levels were measured as well as levels of traditional renal markers like Creatinine and BUN. Data analyzed by Students Unpaired t test. Results demonstrated that difference for BUN & Creatinine between cases (mean BUN=12.46 mg/dl, mean Creatinine=0.7 mg/dl) & controls (mean BUN=8.62 mg/dl, mean Creatinine=0.62 mg/dl) were not statistically significant. But the results showed that difference for Cystatin C (mean for cases 1.86 mg/L and for controls 0.73) was highly significant (P=0.0001). Conclusion- we found that Serum Cystatin C is early and superior marker of renal function in Preeclampsia.

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