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Design of drug molecules for cri du chat syndrome using bio-informatic tools

Author: 
Rabindra Kumar Mishra, Priyadarshini Panda and Ganugula Naveen Kumar
Subject Area: 
Physical Sciences and Engineering
Abstract: 

Our study shows that in addition to proportion and position of the 5p deletion, of the factors may alter the brain function of patients with the 5p deletion. cri du chat syndrome, or 5p deletion syndrome, is a raremedicalconditionthataffects1in50,000newborn. Mental illness depends on the approximate proportion and position ofthe5pdeletion, but in most cases the mental illness is a normal negative for the 5p deletion. He has a soft, gentle voice like a cat. One of the characteristics of new burns is a loud catchy, and this is often considered a diagnosis of illness. However, meowing behaviour observed in individuals whose deletion was limited to 5p15.3 but without the dysmorphic and growth –like condition. Although the size of the deletion varies, in anycasethemainpart deleted is 5p15.2 This paper suggests the type of chemical compound to support the behaviour of the patient includes loudcrying, psychomotor retardation, microcephaly, growth retardation, and craniofacial abnormalities including round face, protrusion, broad nasal bridge and downward-sloping palpebral fissures. We present Some clinical features such as elongated face, large stoma and scoliosis have been reported. This study provide drug, MR level, population genetic and telomere length. Diagnos is may be difficult in some patients with advanced age at first presentation. Some of these have craniofacial features similar to Angelman syndrome. Patients of ten experi encetrauma, self-harm, and violence

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