The Drug trade is a highly organized and creates a global black market economy that is responsible for the crime. However, in case of individuals who consume drugs excessively and commit crimes. These issues play an important role in understanding the risk of crime and drug use. Most addicts should be held liable for most criminals motivated by addiction, but that addiction can affect one’s capacity for self-control over one’s action. Drugs in the form of powders, tablets and capsules, living plants or dried vegetable matter and in liquid are encountered in the Forensic Science Laboratory as Suspected Drugs. The aim of this paper is to describe the most common methods for testing suspected drugs like benzodiazepines, opium, marijuana, etc by physio-chemical method, and recommend the most appreciate analysis by Thin Layer Chromatography for the determination of its purity through Rf value. Drug analysis serves as a formal reference for forensic consideration to identification of suspected drugs that are commonly abused and help the court to determine appreciate sentencing.