The present paper examines the quality of Groundwater in the Study Area of Kalyandurg, Brahmasamudram and Setturu Mandals of Anantapur district of A.P, India. The water quality analysis helps to know the suitability of water for different uses domestic, Agricultural and Industrial suitability of water for various purposes may be studied through important parameters like TDS (Total Dissolved Solids), pH, Chloride (Cl), Calcium (Ca), Magnesium (Mg), and TH (Total Hardness) and Fluoride contents of the water are the parameters by which water quality is here assessed for 2000 and 2012. For this study groundwater quality samples collected from Groundwater Department for different locations in the study area. The study has found that the pH Value in the study area are found in the range between 7.1 to 8.28 and 8.04 to 8.7 in pre and post Monsoon period of 2000, at the same way for 2012 pH range between 7.1 to 7.38 and 7.55 to 7.97, TDS (Total Dissolved Solids) values range between 367.36 to 651.52 Mg/L, and 395.52 to 666.24 Mg/L for 2000, 673.28 to 1256.32 Mg/L and 520.32 to1173.12 Mg/L for pre and post monsoon period of 2011, Chloride (Cl) range between 32 to 56 and 70 to 150 Mg/L in 2000, 100 to 350 and 50 to 300 Mg/L in pre and post monsoon period of 2011, Calcium(Ca) range between 32 to 56 Mg/L and 16 to 40 Mg/L in 2000, 24 to 48 Mg/L and 32 to 64 Mg/L in pre and post monsoon period of 2011, Magnesium (Mg) range between 5 to 49 and 19 to 44 Mg/L in 2000, 39 to 126 and 34 to 78 Mg/L in pre and post monsoon period of 2011 and Total Hardness (TH) values range between 100.6 to 321.6 and 138.2 to 260.5 Mg/L in 2000 and 220.5 to 638.5 and 219.9 to 421.0 Mg/L in pre and post monsoon period of 2011.