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E-Cadherin exon 4-5, exon 7, exon 8, exon 9 and exon 16 mutations in sporadic infiltrating ductal carcinoma of the breast

Author: 
Veeramani Malathi, Kasthuri Revathi, Samuel Masilamoni Ronald and Arunachalam Sundaram
Subject Area: 
Health Sciences
Abstract: 

The cell- cell adhesion molecule E-cadherin is a potent invasion suppressor molecule. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy .Inactivating mutations have been identified for the E-cadherin gene (CDH1) in diffuse gastric cancers and lobular cancer of the breast. Hence in the present study we tried to study the occurrence of tumour specific mutations in exon 4-5, exon7, exon 8, exon 9 and exon 16 of E-cadherin gene in sporadic ductal carcinoma of the Breast. About 50 breast cancer patients were involved in the study. In exon 4-5 we observed 3 mutations ,one deletion mutation and 2 insertion mutation; in exon 7 we observed two deletion mutation; In exon 8 and exon 9 one deletion mutation was observed. In exon 16 one insertion mutation was observed. These mutations are suggestive of loss of growth control and tumour suppressive role of E-cadherin.

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