Background: Chronic Kidney Disease is a major public health problem worldwide with enormous cost burdens on the patients’ in developing countries. The study aims to provide a detailed analysis of the costs of hemodialysis on patients in private hospital in Sudan and provide the different classification of HD costs, and explain to what extent HD patients are able to cover this costs. Methods: This study is an exploratory study, the primary data are obtained from a questionnaire directed to a sample of patients undergoing hemodialysis in private hospital in Khartoum State for six months during August 2015 to February 2016.The cost analysis includes the following types of costs: direct medical costs, indirect medical costs, and indirect costs. Results: The total cost of hemodialysis on patient per session in private hospitals in Sudan was 1648.8 SDG equivalents to ($ 257.6). The annual cost of HD on patient is 158284.8 SDG equivalents to ($ 24732).The direct medical costs (Drugs and investigations costs) have the largest percentage to total HD costs on patients(67.6 percent),10.7 percent of HD costs on patients are direct non-medical costs, while 21.7 percent of HD costs are indirect costs. Many families monthly income is not enough to cover HD cost, these families use various strategies to cope with the high costs of HD.