Cigarette smoking is associated with development and progression of numerous chronic diseases worldwide. In India smoking is a common habit in both rural and urban areas. Cigarette smoking is associated with alterations in inflammatory markers among smokers and it causes various effects on body including blood. It is well recognized that smoking is one of the most important factors contributing to the evolution of atherosclerosis and chronic obstructive pulmonary disease. The aim of this study was the smoking habits and its effect on blood parameters like Total Leukocyte Count, Differential Leukocyte Count, Total Red Blood Cell Count, Hemoglobin concentration and Packed Cell Volume. In this study 50 adult healthy male smokers and 50 adult healthy male non-smokers aged 30 to 60 year were taken from locality of Burla town, Sambalpur, Odisha. The smoker and nonsmoker groups were identified by self implemented questionnaire which was filled by the subjects . TLC, TRBC, Hb, PCV, Eosinophils, Lymphocytes were increased and Neutrophils and Monocytes were decreased in light smoker and heavy smoker in comparison to nonsmoker.