The effect of Mucuna pruriens seed extract on Brain phospholipids was studied in Ethanol treated male pubertal rats. The phospholipid fractions of this rat brain were compared with Ethanol treated and control group rats. The suppressive effect of ethanol on phospholipid fractions was correlated with altered brain function. The application of Mucuna with alcohol relieves the suppressive effect of ethanol, and protects the brain from damage by its anti-oxidants principles. The present study suggests the Mucuna pruriens seed treatment may be beneficial to prevent ethanol-induced toxicity on phospholipids mediated membrane function.