A study was conducted to find the effectiveness of game based learning on knowledge of health promotion among primary school children of selected rural schools of Udupi Taluk Karnataka”. Objectives of the study were to find the effectiveness of game based learning on knowledge of health promotion, and also to find the association between knowledge on health promotion and the selected variables. Demographic proforma and structured knowledge questionnaire on health promotion were administered eighty primary school children selected using proportionate sampling technique. The findings of the study showed that majority 36(45.0%) children belonged to the age group of 10 years, 48(60%) were boys and 41(51.25%) children were in fifth standard. The mean post-test knowledge score in each area of knowledge in the experimental group was higher than the control group. Game based learning was an effective method increase the knowledge level of the higher primary school children. (t=13.77, p=0.001)