CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Established Chonemorpha fragrans callus exhibited biological activities as that of plant extract

Author: 
Renuka Madhu, Anupam J Das, Laxmikanth, G. and Veena, V.
Subject Area: 
Life Sciences
Abstract: 

Chonemorpha fragrans is a medicinal plant used in Indian medicinal systems for the treatment of skeletal gynaecological disorder, stomach disorders, respiratory diseases, rheumatism, skin diseases, diabetes and jaundice. The plant extract shows antipyretic, antidiabetic, anti-parasitic, anticancer and anti-HIV activity. According to International Union for Conservation of Nature (IUCN), the plant is considered to be endangered medicinal plant in the Karnataka and vulnerable in Kerala state of India. The threats for the C. fragrans are due to exploitation of its natural habitat and overexploitation of plant for medicinal use. Conventional propagation by seeds has very low seed viability and the vegetative propagation through stem cutting has low frequency of rooting and low survival rate. The present investigation Chonemorpha fragrans was focused on standardizing the protocol for micropropagation, explore the biological potential such as antimicrobial and anticancer properties of the aqueous and methanolic extract of callus from leaves and leaves alone. The best explants for the direct regeneration were found to be shoot tip as well as single node followed by root and shoot induction. More importantly, the embryogenesis from callus was successfully obtained. Methanolic extract exhibited excellent broad-spectrum antimicrobial activity against human pathogens such as Klebsiella pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis than the aqueous extracts of leaves as well as callus. The anticancer activity revealed that methanolic extract of leaves exhibited inhibition of leukemic cells with the IC50 concentration of 0.3±0.02 and 0.29±0.02 µg ml-1 in HL-60 and K562 cells respectively than the 0.5±0.02 and 0.39±0.02 µg ml-1 methanolic extract of callus in HL-60 and K562 cells respectively. The aqueous extract of leaves showed IC50 concentration of 1.4±0.03 and 1.8±0.04 µg ml-1 in HL-60 and K562 cells respectively aqueous extract of callus showed 1.1±002 and 1.2±0.05 µg ml-1 in HL-60 and K562 cells respectively. These results concluded that the methanolic extract of both callus and leaves of the plant exhibited maximum anticancer activity than aqueous extract of both. The phytochemicals analysis revealed the maximum variety of compounds was present in the methanolic extract which corresponds with the considerable inhibition demonstrated on test microorganisms and cancer cells. These results revealed the optimum micropropagation of medicinal plant that can be used as a natural drug source for modern medicine.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran