Estimation of serum uric acid and lipid profile in patients with coronary artery disease and its causal relationship

Introduction: Coronary artery disease (CAD) is the most common cause of mortality around the world (2). Identification of risk factors and early diagnosis are important as symptoms may indicate unexpected and serious consequences. In addition to genetic predisposition; obesity, diabetes mellitus, dyslipidaemia, hypertension and smoking are well established risk factors. The relationship between increased Serum Uric Acid level and development of CAD has been investigated for more than 50 years. Methods: The study is aimed to find out the significance of raised Serum Uric Acid level in patients with Coronary Artery Disease (CAD). In this study, we included forty CAD patients as test group and equal number of controls. Both test group and control group were selected according to inclusion and exclusion criteria. All candidates were assessed for anthropometric and biochemical parameters. Lipid profiles and Serum Uric Acid was estimated by auto-analyser and IFCC approved methods. Results: The present study showed significant increased level of Total Cholesterol (p< 0.001) and elevated LDL-C (p<0.001) in CAD patients as compared to controls. Mean Uric Acid was also significantly higher in test group (7.83±1.83) as compared to control group (5.06±1.48). Conclusion: Serum Uric Acid, TC/HDL and LDL/HDL ratios could be regarded as objective markers in association with existing atherogenic dyslipidaemia in patients with CAD.