Today, managers of health human resources in nursing face an enormous challenge. Operating within a context of rising demand for health services ,cost containment and shortages of nurses and other health workers , determining the most effective mix of staff and the skills needed by each category of staff to ensure safe, quality and cost effective patient care. Aim: This study aimed to evaluation framework to determine the impact of nursing staff mix decisions in different hospitals; Health Insurance Tanta, Main University and Menshawy Hospitals. Design: descriptive study was be used. Sample: convince sample all 128 head nurses working in different hospitals study. Tool: The data of the study was collected by tool (evaluation framework questionnaire to nursing staff mix decision) includes 2 parts; subject data about the sample and structured. Questionnaire consists of three subscales to evaluation framework structure, process and outcomes. Result: The result indicate that the Health Insurance Hospital follow framework of staff mix evaluation that contribute to best use of the staffing than El-Menshawy and Tanta University Hospital. Also, there is a significance difference found between the three hospitals study related to elements of evaluation for structure, process and outcomes. Recommendation: The study recommended that the different hospital should be follow framework staff-mix decision making to optimal use of nursing care resources and combination or grouping of different categories of workers that is employed for the provision of care to patients.