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Evaluation of pancytopenia by bone marrow examination: experience in a tertiary hospital

Author: 
Dr. Adil H. Siddiqie, Dr. Bilal Musharaf Banday and Dr. Afaq Khan
Subject Area: 
Health Sciences
Abstract: 

Background: Pancytopenia is a common problem encountered in routine hospital practice .It can be a manifestation of relatively trivial treatable cause to serious malignant disorders both haematological as well as non haematological .Bone marrow examination provides a definitive diagnosis for the further management of these patients . Objectives: To study the various patterns of presentation of pancytopenia and use of bone marrow examination as a diagnostic tool. Materials and Methods: It was a prospective study with 108 pancytopenia patients subjected to bone marrow aspiration and biopsy, wherever required in the Department of Pathology Government Medical College Srinagar and its associated hospitals. Results: In 108 patients of pancytopenia subjected to bone marrow examination ,the commonest cause was found to be Megaloblastic Anaemia (52.7%), followed by haematological malignancies (24.07%) Infections accounted for 12.9%of patients Metastasis was seen in 3.7% cases. Aplastic anaemia and PRCA were seen in 1.8% patients each. Conclusion: The causation of pancytopenia is extremely varied and multifactorial. Numerous studies including peripheral smear examination, bone marrow examination can help to arrive at a correct diagnosis which can be confounding at times.

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