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Evaluation of serum Hepcidin level in Sudanese patients with anemia of chronic renal failure

Author: 
Amged Hussen Abdelrhman and Enaam A. Abdelgader
Subject Area: 
Health Sciences
Abstract: 

Background: Anemia of chronic renal disease related to the failure of renal excretory functicn, and to the renal endocrine function, failure of the excretory function leads to an increased demand for red blood cells because of shortening of the red blood cells life span, failure of renal endocrine function leads to decreased erythorpoietic response because of imparid production of erythropoietin.(Krysiak et al., 2015a, Krysiak et al., 2015b) Hepcidinis a major hormonal regulater of iron homeostasis; (Carvalho et al., 2011, Atkinson et al., 2015) Made in the liver, it inhibits iron release from macrophages. (Tesfay et al., 2015) and could be serve as an indicator of functional iron deficiency in portion with renal failure (Lemos Ados et al., 2010) Objective: The purpose of this study was to evaluate the serum hepcidin level in Sudanese patients with anemia of chronic renal failue. Materials and methods: A total 42 patinets diagnosed with anemia of chronic renal failue enrolled in this study, serum was separated from participants for ELISA, to estimate hepcidin level. Results: A total 42 patients diagnosed with ACRF in Sudan, their ages ranged between (13-79) years (mean SD 45 20, the mean value of hepcidin level (13.6) both male 24 (12.7%) and female 18 (14.6%) from different age groups, The hepcidin level showed correlate with duration of disease and with gender (p.value<0.05) the relation of hepicdin level and age the p.value showed that more than 0.05 insignificant, no association with age. Conclusion: In summary we conclude that it has significant correlation of serum hepcidin level with gender and duration of disease, but no association with RBcs parameters and age.

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