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Fibrinogen level among type 2 diabetic sudanese patients with coronary arterial disease

Author: 
Enass A. M. Khalid and Mahdi H. A. Abdalla
Subject Area: 
Health Sciences
Abstract: 

Cardiovascular complications account for nearly 50% of deaths in type 2 diabetes mellitus. Several studies reported that haemostatic factor especially hyperfibrinogenemia is implicated as a source of atherosclerosis and its complications. This study aimed to determine fibrinogen level among type 2 diabetic Sudanese patients with coronary arterial diseases (CAD). Following informed consent, 150 subjects were enrolled: 50 known type 2 diabetic patients with stable coronary arterial disease; 50 known type 2 diabetic patients without history of heart disease and 50 healthy individual as controls. Fibrinogen level was measured by Clauss modified method. HbA1c was measured by "boronate binding assay (using NycoCard Kit). Fibrinogen level was found to be significantly higher in diabetic patients with CAD compared with diabetic patients without CAD (p-value 0.001), with no difference between males and females. Fibrinogen levels were significantly associated with HbA1c levels (p value 0.000) and the duration of diabetes (p value 0.048). Our study concluded that fibrinogen level is higher among type 2 diabetic patients with CAD than diabetic patients without CAD. The elevation of fibrinogen level was significantly associated with uncontrolled diabetes.

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